Single nucleotide polymorphisms of ERβ and coronary atherosclerotic disease in Chinese Han women.

ABSTRACT:

Background

Growing evidence has shown that with the increase of age, the incidence of coronary atherosclerotic disease (CAD) in women increases to equal that of men. Several studies on the single nucleotide polymorphisms [SNPs] seem to provide evidence in support of the protective role estrogen receptor β (ERβ) has in reducing the risk of CAD.

Objective

To determine the association of ERβ SNPs rs1256049 RsaI 1082 A > G and rs4986938 AluI 1730 G > A with coronary atherosclerotic disease in Chinese Han women.

Methods

We designed a nested case-control research, in which 120 case women and 30 control women were selected from the Forensic Medicine Department of Tongji Medical College, HUST. We isolated DNA from their lung paraffin blocks, and then screened for these two SN

SUBMITTER: Shen C 

PROVIDER: S-EPMC4396251 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature