Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer.

ABSTRACT:

Background

There is no reliable marker available for early detection, diagnostic confirmation, or disease prognosis available of prostate cancer (PCa). We aimed to evaluate the function of Cullin-1 and unravel its underlying molecular mechanism to develop novel treatment options equivalent to PCa.

Method

We used immunohistochemistry to analyze the correlation between Cullin-1 expression and clinicopathologic variables and patient survival. The Cullin-1 level was tested in PCa cells. The role of regulation of Cullin-1 in PCa was applied in vitro and vivo. In addition, we further investigated the signaling pathway of Cullin-1 in prostate cancer cell proliferation.

Result

We first discovered that Cullin-1 expression was upregulated in human PCa tissues and inversely rela

SUBMITTER: Jiang H 

PROVIDER: S-EPMC4396298 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature