Synthetically defined glycoprotein vaccines: current status and future directions.

ABSTRACT: Primary examples in vaccine design have shown good levels of carbohydrate-specific antibody generation when raised using extracted or fully synthetic capsular polysaccharide glycans covalently coupled to a protein carrier. Herein, we cover recent clinical developments of carbohydrate-based vaccines and describe how novel cutting-edge methodology for the total synthesis of oligosaccharides and for the precise placement of carbohydrates at pre-determined sites within a protein may be used to further improve the safety and efficacy of glycovaccines.

SUBMITTER: Adamo R 

PROVIDER: S-EPMC4396375 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature