Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics.

ABSTRACT: Background.  Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART). Methods.  Twenty inflammatory markers measured in cohorts of ECs, HIV suppressed noncontrollers, and HIV-uninfected controls were compared using rank-based tests and partial least squares discriminant analysis (PLSDA). Spearman correlations were determined among the inflammatory markers, residual viremia by the single-copy assay, and CD4(+) T cell slope. Results.  Significant differences were seen between cohorts in 15 of the soluble inflammatory markers. Human immunodeficiency virus-1 ECs were found to have the highest levels for all of the markers with the exception of RANTES

SUBMITTER: Li JZ 

PROVIDER: S-EPMC4396431 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature