Integrated analysis reveals microRNA networks coordinately expressed with key proteins in breast cancer.

ABSTRACT:

Background

The role played by microRNAs in the deregulation of protein expression in breast cancer is only partly understood. To gain insight, the combined effect of microRNA and mRNA expression on protein expression was investigated in three independent data sets.

Methods

Protein expression was modeled as a multilinear function of powers of mRNA and microRNA expression. The model was first applied to mRNA and protein expression for 105 selected cancer-associated genes and to genome-wide microRNA expression from 283 breast tumors. The model considered both the effect of one microRNA at a time and all microRNAs combined. In the latter case the Lasso penalized regression method was applied to detect the simultaneous effect of multiple microRNAs.

Results

An interactome m

SUBMITTER: Aure MR 

PROVIDER: S-EPMC4396592 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature