Impact of cross-disorder polygenic risk on frontal brain activation with specific effect of schizophrenia risk.

ABSTRACT: Evidence suggests that there is shared genetic aetiology across the major psychiatric disorders conferred by additive effects of many common variants. Measuring their joint effects on brain function may identify common neural risk mechanisms. We investigated the effects of a cross-disorder polygenic risk score (PGRS), based on additive effects of genetic susceptibility to the five major psychiatric disorders, on brain activation during performance of a language-based executive task. We examined this relationship in healthy individuals with (n=82) and without (n=57) a family history of bipolar disorder to determine whether this effect was additive or interactive dependent on the presence of family history. We demonstrate a significant interaction for polygenic loading×group in left lateral

SUBMITTER: Whalley HC 

PROVIDER: S-EPMC4396692 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature