Phenotype-genotype correlations of facial width and height proportions in patients with Class II malocclusion.

ABSTRACT:

Objectives

To characterize soft-tissue facial height and width variation in Class II malocclusion and test for correlations with genes HMGA2, AJUBA, and ADK.

Setting and sample population

Nine facial proportions were estimated from 2D frontal repose photographs of 330 Caucasian adults with Class II malocclusion.

Material and methods

After adjustments for age and gender, the facial proportions were submitted to a principal component analyses (PCA). The most meaningful phenotypic variations were correlated with SNPs rs7924176 (ADK), rs17101923 (HMGA2), and rs997154 (AJUBA) genotyped in 106 individuals.

Results

Principal component analyses resulted in four principal components (PCs), which explained 75% of total variation. PC1 captured variation in the intercanthu

SUBMITTER: Moreno Uribe LM 

PROVIDER: S-EPMC4396710 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature