Blood transfusions in septic shock: is 7.0 g/dL really the appropriate threshold?

ABSTRACT:

Objective

To evaluate the immediate effects of red blood cell transfusion on central venous oxygen saturation and lactate levels in septic shock patients with different transfusion triggers.

Methods

We included patients with a diagnosis of septic shock within the last 48 hours and hemoglobin levels below 9.0 g/dL Patients were randomized for immediate transfusion with hemoglobin concentrations maintained above 9.0 g/dL (Group Hb9) or to withhold transfusion unless hemoglobin felt bellow 7.0 g/dL (Group Hb7). Hemoglobin, lactate, central venous oxygen saturation levels were determined before and one hour after each transfusion.

Results

We included 46 patients and 74 transfusions. Patients in Group Hb7 had a significant reduction in median lactate from 2.44 (2.00 - 3.22

SUBMITTER: Mazza BF 

PROVIDER: S-EPMC4396895 | biostudies-literature | 2015 Jan-Mar

REPOSITORIES: biostudies-literature