C-reactive protein as a marker of melanoma progression.

ABSTRACT:

Purpose

To investigate the association between blood levels of C-reactive protein (CRP) in patients with melanoma and overall survival (OS), melanoma-specific survival (MSS), and disease-free survival.

Patients and methods

Two independent sets of plasma samples from a total of 1,144 patients with melanoma (587 initial and 557 confirmatory) were available for CRP determination. Kaplan-Meier method and Cox regression were used to evaluate the relationship between CRP and clinical outcome. Among 115 patients who underwent sequential blood draws, we evaluated the relationship between change in disease status and change in CRP using nonparametric tests.

Results

Elevated CRP level was associated with poorer OS and MSS in the initial, confirmatory, and combined data sets (co

SUBMITTER: Fang S 

PROVIDER: S-EPMC4397281 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature