Interactions between innate immunity genes and early-life risk factors in allergic rhinitis.

ABSTRACT:

Purpose

Allergic rhinitis (AR) is a common chronic disease. Many factors could affect the development of AR. We investigated early-life factors, such as delivery mode, feeding method, and use of antibiotics during infancy, which could affect the development of AR. In addition, how interactions between these factors and innate gene polymorphisms influence the development of AR was investigated.

Methods

A cross-sectional study of 1,828 children aged 9-12 years was conducted. Three early-life factors and AR were assessed by a questionnaire. Skin prick tests were done. Polymorphisms of TLR4 (rs1927911) and CD14 (rs2569190) were genotyped.

Results

Use of antibiotics during infancy increased the risk of AR (aOR [95% CI] 1.511 [1.222-2.037]) and atopic AR (aOR [95% CI], 1.56

SUBMITTER: Seo JH 

PROVIDER: S-EPMC4397364 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature