Copy number variation burden on asthma subgenome in normal cohorts identifies susceptibility markers.

ABSTRACT:

Purpose

Asthma is a complex disease caused by interplay of genes and environment on the genome of an individual. Copy number variations (CNVs) are more common compared to the other variations that disrupt genome organization. The effect of CNVs on asthma subgenome has been less studied compared to studies on the other variations. We report the assessments of CNV burden in asthma genes of normal cohorts carried out in different geographical areas of the world and discuss the relevance of the observation with respect to asthma pathogenesis.

Methods

CNV analysis was performed using Affymerix high-resolution arrays, and various bioinformatics tools were used to understand the influence of genes on asthma pathogenesis.

Results

This study identified 61 genes associated with

SUBMITTER: Vishweswaraiah S 

PROVIDER: S-EPMC4397367 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature