Endocannabinoid signaling within the basolateral amygdala integrates multiple stress hormone effects on memory consolidation.

ABSTRACT: Glucocorticoid hormones are known to act synergistically with other stress-activated neuromodulatory systems, such as norepinephrine and corticotropin-releasing factor (CRF), within the basolateral complex of the amygdala (BLA) to induce optimal strengthening of the consolidation of long-term memory of emotionally arousing experiences. However, as the onset of these glucocorticoid actions appear often too rapid to be explained by genomic regulation, the neurobiological mechanism of how glucocorticoids could modify the memory-enhancing properties of norepinephrine and CRF remained elusive. Here, we show that the endocannabinoid system, a rapidly activated retrograde messenger system, is a primary route mediating the actions of glucocorticoids, via a glucocorticoid receptor on the cell surfa

SUBMITTER: Atsak P 

PROVIDER: S-EPMC4397407 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature