Functional and effective hippocampal-neocortical connectivity during construction and elaboration of autobiographical memory retrieval.

ABSTRACT: Autobiographical memory (AM) provides the opportunity to study interactions among brain areas that support the search for a specific episodic memory (construction), and the later experience of mentally reliving it (elaboration). While the hippocampus supports both construction and elaboration, it is unclear how hippocampal-neocortical connectivity differs between these stages, and how this connectivity involves the anterior and posterior segments of the hippocampus, as these have been considered to support the retrieval of general concepts and recollection processes, respectively. We acquired fMRI data in 18 healthy participants during an AM retrieval task in which participants were asked to access a specific AM (construction) and then to recollect it by recovering as many episodic details

SUBMITTER: McCormick C 

PROVIDER: S-EPMC4397572 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature