Association of OCT derived drusen measurements with AMD associated-genotypic SNPs in Amish population.

ABSTRACT:

Purpose

To investigate the association of OCT derived drusen measures in Amish age-related macular degeneration (AMD) patients with known loci for macular degeneration.

Methods

Members of the Old Order Amish community in Pennsylvania ages 50 and older were assessed for drusen area, volume and regions of retinal pigment epithelium (RPE) atrophy using a Cirrus High- Definition-OCT. Measurements were obtained in the macula region within a central circle (CC) of 3 mm diameter and a surrounding perifoveal ring (PR) of 3 to 5 mm diameter using the Cirrus OCT RPE analysis software. Other demographic information including age, gender and smoking status were collected. Study subjects were further genotyped to determine their risk for the AMD associated SNPs in SYN3, LIPC, ARMS2, C

SUBMITTER: Chavali VR 

PROVIDER: S-EPMC4398021 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature