Estimating glomerular filtration rate from serum creatinine and cystatin C.

ABSTRACT:

Background

Estimates of glomerular filtration rate (GFR) that are based on serum creatinine are routinely used; however, they are imprecise, potentially leading to the overdiagnosis of chronic kidney disease. Cystatin C is an alternative filtration marker for estimating GFR.

Methods

Using cross-sectional analyses, we developed estimating equations based on cystatin C alone and in combination with creatinine in diverse populations totaling 5352 participants from 13 studies. These equations were then validated in 1119 participants from 5 different studies in which GFR had been measured. Cystatin and creatinine assays were traceable to primary reference materials.

Results

Mean measured GFRs were 68 and 70 ml per minute per 1.73 m(2) of body-surface area in the developmen

SUBMITTER: Inker LA 

PROVIDER: S-EPMC4398023 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature