Three-dimensional analysis of tumour vascular corrosion casts using stereoimaging and micro-computed tomography.

ABSTRACT:

Objective

In order to perform effective translational research for cancer therapy, we need to employ pre-clinical models which reflect the clinical situation. The purpose of this study was to quantitatively compare the vascular architecture of human colorectal cancer and experimental tumour models to determine the suitability of animal models for vascular studies and antivascular therapy.

Methods

In this study we investigated the three-dimensional properties of colonic tumour vasculature in both human clinical tissues (normal mucosa control [n=20], carcinoma [n=20] and adenoma [n=6]) and murine colorectal xenografts (LS147T [n=6] and SW1222 [n=6]). Scanning Electron Microscope Stereoimaging (SEM) and X-ray Micro-Computed Tomography (Micro-CT) methods were employed for 3D ana

SUBMITTER: Folarin AA 

PROVIDER: S-EPMC4398341 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature