Impaired tilt perception in Parkinson's disease: a central vestibular integration failure.

ABSTRACT:

Introduction

Impaired balance control is a hallmark symptom in Parkinson's disease (PD). Altered sensory-motor integration contributes to the deficiency. We aimed to determine whether impaired vestibular signal processing added to the disorder. We exposed patients (N = 11; 68±6y) and age-matched healthy subjects (hS: N = 19; 65±11y) on a motion platform in complete darkness to two consecutive forward tilt movements (12 series; N = 24; overall 288 trials) and asked them to indicate which tilt was perceived larger. By combing tilt movements with translations we manipulated vestibular sensory input in order to investigate whether putative impairment resulted from a deficiency of the sensory organs (semicircular canals in 'single-SCC-cue-condition', otoliths in 'single-OT-cue-condition

SUBMITTER: Bertolini G 

PROVIDER: S-EPMC4398395 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature