Postnatal loss of hap1 reduces hippocampal neurogenesis and causes adult depressive-like behavior in mice.

ABSTRACT: Depression is a serious mental disorder that affects a person's mood, thoughts, behavior, physical health, and life in general. Despite our continuous efforts to understand the disease, the etiology of depressive behavior remains perplexing. Recently, aberrant early life or postnatal neurogenesis has been linked to adult depressive behavior; however, genetic evidence for this is still lacking. Here we genetically depleted the expression of huntingtin-associated protein 1 (Hap1) in mice at various ages or in selective brain regions. Depletion of Hap1 in the early postnatal period, but not later life, led to a depressive-like phenotype when the mice reached adulthood. Deletion of Hap1 in adult mice rendered the mice more susceptible to stress-induced depressive-like behavior. Furthermore, ea

SUBMITTER: Xiang J 

PROVIDER: S-EPMC4398408 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature