Association of guideline-based antimicrobial therapy and outcomes in healthcare-associated pneumonia.

ABSTRACT:

Objectives

Guidelines for treatment of healthcare-associated pneumonia (HCAP) recommend empirical therapy with broad-spectrum antimicrobials. Our objective was to examine the association between guideline-based therapy (GBT) and outcomes for patients with HCAP.

Patients and methods

We conducted a pharmacoepidemiological cohort study at 346 US hospitals. We included adults hospitalized between July 2007 and June 2010 for HCAP, defined as patients admitted from a nursing home, with end-stage renal disease or immunosuppression, or discharged from a hospital in the previous 90 days. Outcome measures included in-hospital mortality, length of stay and costs.

Results

Of 85 097 patients at 346 hospitals, 31 949 (37.5%) received GBT (one agent against MRSA and at least one aga

SUBMITTER: Rothberg MB 

PROVIDER: S-EPMC4398467 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature