Stage-specific effects of fibroblast growth factor 2 on the differentiation of dental pulp cells.

ABSTRACT: Dentinogenesis is a complex and multistep process, which is regulated by various growth factors, including members of the fibroblast growth factor (FGF) family. Both positive and negative effects of FGFs on dentinogenesis have been reported, but the underlying mechanisms of these conflicting results are still unclear. To gain a better insight into the role of FGF2 in dentinogenesis, we used dental pulp cells from various transgenic mice, in which fluorescent protein expression identifies cells at different stages of odontoblast differentiation. Our results showed that the continuous exposure of pulp cells to FGF2 inhibited mineralization and revealed both the stimulatory and inhibitory effects of FGF2 on the expression of markers of dentinogenesis and various transgenes. During the prolife

SUBMITTER: Sagomonyants K 

PROVIDER: S-EPMC4398604 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature