Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion.

ABSTRACT:

Unlabelled

Autophagy is a mechanism by which cells degrade cellular material to provide nutrients and energy for survival during stress. The autophagy is thought to be a critical process for cancer stem cell (CSC) or tumor-initiating cell maintenance but the mechanisms by which autophagy supports survival of CSCs remain poorly understood. In this study, inhibition of autophagy by knockdown of ATG7 or BECN1 modified the CD44(+)/CD24(low/-) population in breast cancer cells by regulating CD24 and IL6 secretion. In a breast cancer cell line that is independent of autophagy for survival, autophagy inhibition increased IL6 secretion to the media. On the other hand, in an autophagy-dependent cell line, autophagy inhibition decreased IL6 secretion, cell survival, and mammosphere formation

SUBMITTER: Maycotte P 

PROVIDER: S-EPMC4398616 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature