P53 and ΔNp63α Coregulate the Transcriptional and Cellular Response to TGFβ and BMP Signals.

ABSTRACT:

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The TGFβ superfamily regulates a broad range of cellular processes, including proliferation, cell-fate specification, differentiation, and migration. Molecular mechanisms underlying this high degree of pleiotropy and cell-type specificity are not well understood. The TGFβ family is composed of two branches: (i) TGFβs, activins, and nodals, which signal through SMAD2/3, and (ii) bone morphogenetic proteins (BMP), which signal through SMAD1/5/8. SMADs have weak DNA-binding affinity and rely on coactivators and corepressors to specify their transcriptional outputs. This report reveals that p53 and ΔNp63α act as transcriptional partners for SMAD proteins and thereby influence cellular responses to TGFβ and BMPs. Suppression of p53 or overexpression of ΔNp63α synergistically

SUBMITTER: Balboni AL 

PROVIDER: S-EPMC4398640 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature