Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: the Mayo Clinic Study of Aging.

ABSTRACT:

Background

Etiologic differences in mild cognitive impairment (MCI) subtypes may impact mortality.

Objective

To assess the rate of death in MCI overall, and by subtype, in the population-based Mayo Clinic Study of Aging.

Methods

Participants aged 70-89 years at enrollment were clinically evaluated at baseline and 15-month intervals to assess diagnoses of MCI and dementia. Mortality in MCI cases versus cognitively normal (CN) individuals was estimated using Cox proportional hazards models.

Results

Over a median follow-up of 5.8 years, 331 of 862 (38.4%) MCI cases and 224 of 1,292 (17.3%) cognitively normal participants died. Compared to CN individuals, mortality was elevated in persons with MCI (hazard ratio [HR] = 1.79; 95% CI: 1.41 to 2.27), and was higher for

SUBMITTER: Vassilaki M 

PROVIDER: S-EPMC4398642 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature