Impact of malaria preexposure on antiparasite cellular and humoral immune responses after controlled human malaria infection.

ABSTRACT: To understand the effect of previous malaria exposure on antiparasite immune responses is important for developing successful immunization strategies. Controlled human malaria infections (CHMIs) using cryopreserved Plasmodium falciparum sporozoites provide a unique opportunity to study differences in acquisition or recall of antimalaria immune responses in individuals from different transmission settings and genetic backgrounds. In this study, we compared antiparasite humoral and cellular immune responses in two cohorts of malaria-naive Dutch volunteers and Tanzanians from an area of low malarial endemicity, who were subjected to the identical CHMI protocol by intradermal injection of P. falciparum sporozoites. Samples from both trials were analyzed in parallel in a single center to ensure

SUBMITTER: Obiero JM 

PROVIDER: S-EPMC4399069 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature