Methamphetamine induces alterations in the long non-coding RNAs expression profile in the nucleus accumbens of the mouse.

ABSTRACT:

Background

Repeated exposure to addictive drugs elicits long-lasting cellular and molecular changes. It has been reported that the aberrant expression of long non-coding RNAs (lncRNAs) is involved in cocaine and heroin addiction, yet the expression profile of lncRNAs and their potential effects on methamphetamine (METH)-induced locomotor sensitization are largely unknown.

Results

Using high-throughput strand-specific complementary DNA sequencing technology (ssRNA-seq), here we examined the alterations in the lncRNAs expression profile in the nucleus accumbens (NAc) of METH-sensitized mice. We found that the expression levels of 6246 known lncRNAs (6215 down-regulated, 31 up-regulated) and 8442 novel lncRNA candidates (8408 down-regulated, 34 up-regulated) were significantly

SUBMITTER: Zhu L 

PROVIDER: S-EPMC4399149 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature