Effect of increased leptin and C-reactive protein levels on mortality: results from the National Health and Nutrition Examination Survey.

ABSTRACT:

Objective

Leptin and C-reactive protein (CRP) have each been linked to adverse cardiovascular events, and prior cross-sectional research suggests that increased levels of both biomarkers pose an even greater risk. The effect of increased levels of both leptin and CRP on mortality has not, however, been previously assessed.

Methods

We used data from the third National Health and Nutrition Examination Survey (NHANES III) to estimate the mortality effect of high leptin and high CRP levels. Outcomes were compared with the use of inverse-probability-weighting adjustment. Among 6259 participants included in the analysis, 766 were in their sex-specific, population-weighted highest quartiles of both leptin and CRP. Median follow-up time was 14.3 years.

Results

There was no si

SUBMITTER: Amrock SM 

PROVIDER: S-EPMC4399234 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature