The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Program outcomes study 10-year follow-up.

ABSTRACT:

Context

Gestational diabetes (GDM) confers a high risk of type 2 diabetes. In the Diabetes Prevention Program (DPP), intensive lifestyle (ILS) and metformin prevented or delayed diabetes in women with a history of GDM.

Objective

The objective of the study was to evaluate the impact of ILS and metformin intervention over 10 years in women with and without a history of GDM in the DPP/Diabetes Prevention Program Outcomes Study.

Design

This was a randomized controlled clinical trial with an observational follow-up.

Setting

The study was conducted at 27 clinical centers.

Participants

Three hundred fifty women with a history of GDM and 1416 women with previous live births but no history of GDM participated in the study. The participants had an elevated body ma

SUBMITTER: Aroda VR 

PROVIDER: S-EPMC4399293 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature