Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.

ABSTRACT:

Context

Skeletal muscle from sedentary older adults exhibits reduced mitochondrial abundance and oxidative capacity.

Objective

The primary objective was to determine whether 8 weeks of combined training (CT) has a more robust effect than endurance training (ET) or resistance training (RT) on mitochondrial physiology in healthy young (18-30 years) and older (≥ 65 years) adults.

Intervention

Thirty-four young and 31 older adults were randomly assigned to 8 weeks of ET, RT, and control/CT. Control subjects completed 8 weeks of no exercise (control) followed by 8 weeks of CT. Body composition, skeletal muscle strength, and peak oxygen uptake were measured before and after the intervention. Vastus lateralis muscle biopsy samples were obtained before and 48 hours after the

SUBMITTER: Irving BA 

PROVIDER: S-EPMC4399307 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature