Genomic rearrangements define lineage relationships between adjacent lepidic and invasive components in lung adenocarcinoma.

ABSTRACT: The development of adenocarcinoma of the lung is believed to proceed from in situ disease (adenocarcinoma in situ, AIS) to minimally invasive disease with prominent lepidic growth (minimally invasive adenocarcinoma, MIA), then to fully invasive adenocarcinoma (AD), but direct evidence for this model has been lacking. Because some lung adenocarcinomas show prominent lepidic growth (AD-L), we designed a study to address the lineage relationship between the lepidic (noninvasive) component (L) and the adjacent nonlepidic growth component representing invasive disease within individual tumors. Lineage relationships were evaluated by next-generation DNA sequencing to define large genomic rearrangements in microdissected tissue specimens collected by laser capture. We found a strong lineage relat

SUBMITTER: Murphy SJ 

PROVIDER: S-EPMC4399556 | biostudies-literature | 2014 Jun

REPOSITORIES: biostudies-literature