Time to benefit for colorectal cancer screening: survival meta-analysis of flexible sigmoidoscopy trials.

ABSTRACT:

Objective

To determine the time to benefit of using flexible sigmoidoscopy for colorectal cancer screening.

Design

Survival meta-analysis.

Data sources

A Cochrane Collaboration systematic review published in 2013, Medline, and Cochrane Library databases.

Eligibility criteria

Randomized controlled trials comparing screening flexible sigmoidoscopy with no screening. Trials with fewer than 100 flexible sigmoidoscopy screenings were excluded.

Results

Four studies were eligible (total n = 459,814). They were similar for patients' age (50-74 years), length of follow-up (11.2-11.9 years), and relative risk for colorectal cancer related mortality (0.69-0.78 with flexible sigmoidoscopy screening). For every 1000 people screened at five and 10 years, 0.3 and 1.2 c

SUBMITTER: Tang V 

PROVIDER: S-EPMC4399600 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature