Dataset Information

Roles of estrogen in the formation of intracranial aneurysms in ovariectomized female mice.

ABSTRACT:

Background

Epidemiological studies have indicated that postmenopausal women have a higher incidence of intracranial aneurysms than men in the same age group.

Objective

To investigate whether estrogen or estrogen receptors (ERs) mediate protective effects against the formation of intracranial aneurysms.

Methods

Intracranial aneurysms were induced in mice by combining a single injection of elastase into the cerebrospinal fluid with deoxycorticosterone acetate salt hypertension. The mice were treated with estrogen (17β-estradiol), an ERα agonist (propyl pyrazole triol), and an ERβ agonist (diarylpropionitrile) with and without a nitric oxide synthase inhibitor.