Intratumoral injection of Clostridium novyi-NT spores induces antitumor responses.

ABSTRACT: Species of Clostridium bacteria are notable for their ability to lyse tumor cells growing in hypoxic environments. We show that an attenuated strain of Clostridium novyi (C. novyi-NT) induces a microscopically precise, tumor-localized response in a rat orthotopic brain tumor model after intratumoral injection. It is well known, however, that experimental models often do not reliably predict the responses of human patients to therapeutic agents. We therefore used naturally occurring canine tumors as a translational bridge to human trials. Canine tumors are more like those of humans because they occur in animals with heterogeneous genetic backgrounds, are of host origin, and are due to spontaneous rather than engineered mutations. We found that intratumoral injection of C. novyi-NT spores wa

SUBMITTER: Roberts NJ 

PROVIDER: S-EPMC4399712 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature