Synthetic lethals in HIV: ways to avoid drug resistance : Running title: Preventing HIV resistance.

ABSTRACT:

Background

RNA viruses rapidly accumulate genetic variation, which can give rise to synthetic lethal (SL) and deleterious (SD) mutations. Synthetic lethal mutations (non-lethal when alone but lethal when combined in one genome) have been studied to develop cancer therapies. This principle can also be used against fast-evolving RNA-viruses. Indeed, targeting protein sites involved in SD + SL interactions with a drug would render any mutation of such sites, lethal.

Results

Here, we set up a strategy to detect intragenic pairs of SL and SD at the surface of the protein to predict less escapable drug target sites. For this, we detected SD + SL, studying HIV protease (PR) and reverse transcriptase (RT) sequence alignments from two groups of VIH(+) individuals: treated with drugs

SUBMITTER: Petitjean M 

PROVIDER: S-EPMC4399722 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature