Inhibition of histone deacetylases facilitates extinction and attenuates reinstatement of nicotine self-administration in rats.

ABSTRACT: Chromatin remodelling is integral to the formation of long-term memories. Recent evidence suggests that histone modification may play a role in the persistence of memories associated with drug use. The present series of experiments aimed to examine the effect of histone deacetylase (HDAC) inhibition on the extinction and reinstatement of nicotine self-administration. Rats were trained to intravenously self-administer nicotine for 12 days on a fixed-ratio 1 schedule. In Experiment 1, responding was then extinguished through removal of nicotine and response-contingent cues. After each extinction session, the HDAC inhibitor, sodium butyrate (NaB), was administered immediately, or six hours after each session. In Experiment 2, response-contingent cues remained available across extinction to in

SUBMITTER: Castino MR 

PROVIDER: S-EPMC4399837 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature