High serum β-lactams specific/total IgE ratio is associated with immediate reactions to β-lactams antibiotics.

ABSTRACT: Total serum IgE result from the combination of specific and non-specific pools. High specific/total IgE ratio may reflect high level of allergen-specific IgE on mast cells. No data regarding its applications to drug allergies is available. One hundred seventy-one patients with a history of immediate reactions to β-lactams, confirmed by positive skin testing, and 122 control subjects tolerant to β-lactams, were studied. CAP System was used for the detection of serum total and specific IgE antibodies. The specific/total IgE ratio was tested for diagnostic accuracy compared with conventional criteria. We finally performed a simulation study to expand our investigation of the performance of the specific/total IgE ratio index in a scenario in which the new CAP detection threshold is lowered fur

SUBMITTER: Vultaggio A 

PROVIDER: S-EPMC4399843 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature