Proteomics perspectives in rotator cuff research: a systematic review of gene expression and protein composition in human tendinopathy.

ABSTRACT:

Background

Rotator cuff tendinopathy including tears is a cause of significant morbidity. The molecular pathogenesis of the disorder is largely unknown. This review aimed to present an overview of the literature on gene expression and protein composition in human rotator cuff tendinopathy and other tendinopathies, and to evaluate perspectives of proteomics--the comprehensive study of protein composition--in tendon research.

Materials and methods

We conducted a systematic search of the literature published between 1 January 1990 and 18 December 2012 in PubMed, Embase, and Web of Science. We included studies on objectively quantified differential gene expression and/or protein composition in human rotator cuff tendinopathy and other tendinopathies as compared to control tissue

SUBMITTER: Sejersen MH 

PROVIDER: S-EPMC4400011 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature