Directed network motifs in Alzheimer's disease and mild cognitive impairment.

ABSTRACT: Directed network motifs are the building blocks of complex networks, such as human brain networks, and capture deep connectivity information that is not contained in standard network measures. In this paper we present the first application of directed network motifs in vivo to human brain networks, utilizing recently developed directed progression networks which are built upon rates of cortical thickness changes between brain regions. This is in contrast to previous studies which have relied on simulations and in vitro analysis of non-human brains. We show that frequencies of specific directed network motifs can be used to distinguish between patients with Alzheimer's disease (AD) and normal control (NC) subjects. Especially interesting from a clinical standpoint, these motif frequencies c

SUBMITTER: Friedman EJ 

PROVIDER: S-EPMC4400037 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature