Estimating dengue transmission intensity from sero-prevalence surveys in multiple countries.

ABSTRACT:

Background

Estimates of dengue transmission intensity remain ambiguous. Since the majority of infections are asymptomatic, surveillance systems substantially underestimate true rates of infection. With advances in the development of novel control measures, obtaining robust estimates of average dengue transmission intensity is key for assessing both the burden of disease from dengue and the likely impact of interventions.

Methodology/principal findings

The force of infection (λ) and corresponding basic reproduction numbers (R0) for dengue were estimated from non-serotype (IgG) and serotype-specific (PRNT) age-stratified seroprevalence surveys identified from the literature. The majority of R0 estimates ranged from 1-4. Assuming that two heterologous infections result in compl

SUBMITTER: Imai N 

PROVIDER: S-EPMC4400108 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature