Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis.

ABSTRACT:

Study question

Are STAT3 signaling molecules differentially expressed in endometriosis?

Summary answer

Levels of phospho-STAT3 and HIF1A, its downstream signaling molecule, are significantly higher in eutopic endometrium from women with endometriosis when compared with women without the disease.

What is known already

Endometriosis is an estrogen-dependent inflammatory condition. Interleukin 6 (IL-6) is an inflammatory survival cytokine known to induce prolonged activation of STAT3 via association with the IL-6 receptor.

Study design, size, duration

Cross-sectional measurements of STAT3 and HIF1A protein levels in eutopic endometrium from women with endometriosis versus those without.

Participants/materials, setting, methods

Levels of phospho-STAT3 (pSTAT

SUBMITTER: Kim BG 

PROVIDER: S-EPMC4400199 | biostudies-literature | 2015 May

REPOSITORIES: biostudies-literature