Robust optimization in intensity-modulated proton therapy to account for anatomy changes in lung cancer patients.

ABSTRACT:

Background and purpose

Robust optimization for IMPT takes setup and range uncertainties into account during plan optimization. However, anatomical changes were not prospectively included. The purpose of this study was to examine robustness and dose variation due to setup uncertainty and anatomical change in IMPT of lung cancer.

Material and methods

Plans were generated with multi-field optimization based on planning target volume (MFO-PTV) and worst-case robust optimization (MFO-RO) on simulation computed tomography scans (CT0) for nine patients. Robustness was evaluated on the CT0 by computing the standard deviation of DVH (SD-DVH). Dose variations calculated on weekly CTs were compared with SD-DVH. Equivalent uniform dose (EUD) change from the original plan on weekly dose

SUBMITTER: Li H 

PROVIDER: S-EPMC4400219 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature