Oncogenic osteomalacia illustrating the effect of fibroblast growth factor 23 on phosphate homeostasis.

ABSTRACT: In oncogenic osteomalacia (OOM), fibroblast growth factor 23 (FGF23) induces renal phosphate wasting and inhibits the appropriate increase of calcitriol. A patient suffering from OOM is described. Serum calcium, phosphate, biointact parathyroid hormone and intact FGF23 as well as the calcitriol and 24,25-vitamin D levels were measured before and after tumour removal. The clinical approach to a patient with hypophosphataemia is discussed and the changes in mineral metabolism after removal of a FGF23-producing tumour are described.

SUBMITTER: Westerberg PA 

PROVIDER: S-EPMC4400509 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature