Examination of autoantibody status and clinical features associated with cancer risk and cancer-associated scleroderma.

ABSTRACT:

Objective

We previously reported a contemporaneous onset of cancer and scleroderma in patients with anti-RNA polymerase III antibodies, and we identified a biologic link between cancer and scleroderma. This investigation was designed to further evaluate whether autoantibody status and other characteristics are associated with cancer and a clustering of cancer with scleroderma onset.

Methods

Logistic regression analysis was performed to assess the relationship of 2 outcomes, cancer (model 1) and a short (±2 years) cancer-scleroderma interval (model 2), with autoantibody status and scleroderma covariates.

Results

Of 1,044 scleroderma patients, 168 (16.1%) had cancer. In the adjusted model 1, only older age at scleroderma onset (odds ratio 1.04 [95% confidence interval 1

SUBMITTER: Shah AA 

PROVIDER: S-EPMC4400658 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature