FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response.

ABSTRACT:

Objective

Kawasaki disease (KD), response to intravenous immunoglobulin (IVIG) therapy, and associated coronary artery disease progression have been associated with genetic polymorphisms in Fc gamma receptor (FcγR) genes. However, it is not known whether the existing gene copy number (GCN) variability relates to KD treatment response, susceptibility, or associated sequelae.

Methods

The copy number of individuals with KD (n=510) and their family members (n=808) for three variable FcγRs was assessed using pyrosequencing. We performed the transmission disequilibrium test to examine the association of GCN for FcγRs (FcγR2C, FcγR3A, and FcγR3B) with susceptibility and used logistic regression models to determine its association with IVIG treatment outcomes.

Results

FcγR2C

SUBMITTER: Makowsky R 

PROVIDER: S-EPMC4400828 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature