Neural organization of spoken language revealed by lesion-symptom mapping.

ABSTRACT: Studies of patients with acquired cognitive deficits following brain damage and studies using contemporary neuroimaging techniques form two distinct streams of research on the neural basis of cognition. In this study, we combine high-quality structural neuroimaging analysis techniques and extensive behavioural assessment of patients with persistent acquired language deficits to study the neural basis of language. Our results reveal two major divisions within the language system-meaning versus form and recognition versus production-and their instantiation in the brain. Phonological form deficits are associated with lesions in peri-Sylvian regions, whereas semantic production and recognition deficits are associated with damage to the left anterior temporal lobe and white matter connectivity

SUBMITTER: Mirman D 

PROVIDER: S-EPMC4400840 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature