Ontology highlight
ABSTRACT:
SUBMITTER: Fu H
PROVIDER: S-EPMC4400873 | biostudies-literature | 2015 Apr
REPOSITORIES: biostudies-literature
Nature communications 20150416
The Mus81 endonuclease resolves recombination intermediates and mediates cellular responses to exogenous replicative stress. Here, we show that Mus81 also regulates the rate of DNA replication during normal growth by promoting replication fork progression while reducing the frequency of replication initiation events. In the absence of Mus81 endonuclease activity, DNA synthesis is slowed and replication initiation events are more frequent. In addition, Mus81-deficient cells fail to recover from e ...[more]