DAP12 expression in lung macrophages mediates ischemia/reperfusion injury by promoting neutrophil extravasation.

ABSTRACT: Neutrophils are critical mediators of innate immune responses and contribute to tissue injury. However, immune pathways that regulate neutrophil recruitment to injured tissues during noninfectious inflammation remain poorly understood. DAP12 is a cell membrane-associated protein that is expressed in myeloid cells and can either augment or dampen innate inflammatory responses during infections. To elucidate the role of DAP12 in pulmonary ischemia/reperfusion injury (IRI), we took advantage of a clinically relevant mouse model of transplant-mediated lung IRI. This technique allowed us to dissect the importance of DAP12 in tissue-resident cells and those that infiltrate injured tissue from the periphery during noninfectious inflammation. Macrophages in both mouse and human lungs that have bee

SUBMITTER: Spahn JH 

PROVIDER: S-EPMC4401083 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature