Neutrophil recruitment to lymph nodes limits local humoral response to Staphylococcus aureus.

ABSTRACT: Neutrophils form the first line of host defense against bacterial pathogens. They are rapidly mobilized to sites of infection where they help marshal host defenses and remove bacteria by phagocytosis. While splenic neutrophils promote marginal zone B cell antibody production in response to administered T cell independent antigens, whether neutrophils shape humoral immunity in other lymphoid organs is controversial. Here we investigate the neutrophil influx following the local injection of Staphylococcus aureus adjacent to the inguinal lymph node and determine neutrophil impact on the lymph node humoral response. Using intravital microscopy we show that local immunization or infection recruits neutrophils from the blood to lymph nodes in waves. The second wave occurs temporally with neutrop

SUBMITTER: Kamenyeva O 

PROVIDER: S-EPMC4401519 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature