Update on the autoimmune pathology of multiple sclerosis: B-cells as disease-drivers and therapeutic targets.

ABSTRACT:

Background

Collectively, research on the role of B-cells in the pathogenesis of multiple sclerosis (MS) illustrates how translational medicine has given rise to promising therapeutic approaches for one of the most debilitating chronic neurological diseases in young adults. First described in 1935, the experimental autoimmune/allergic encephalomyelitis model is a key animal model that has provided the foundation for important developments in targeted therapeutics.

Summary

While additional B-cell therapies for MS are presently being developed by the pharmaceutical industry, much remains to be understood about the role played by B-cells in MS. The goal of this review is to summarize how B-cells may contribute to MS pathogenesis and thereby provide a basis for understanding why

SUBMITTER: von Budingen HC 

PROVIDER: S-EPMC4401636 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature