Emergent systems energy laws for predicting myosin ensemble processivity.

ABSTRACT: In complex systems with stochastic components, systems laws often emerge that describe higher level behavior regardless of lower level component configurations. In this paper, emergent laws for describing mechanochemical systems are investigated for processive myosin-actin motility systems. On the basis of prior experimental evidence that longer processive lifetimes are enabled by larger myosin ensembles, it is hypothesized that emergent scaling laws could coincide with myosin-actin contact probability or system energy consumption. Because processivity is difficult to predict analytically and measure experimentally, agent-based computational techniques are developed to simulate processive myosin ensembles and produce novel processive lifetime measurements. It is demonstrated that only syst

SUBMITTER: Egan P 

PROVIDER: S-EPMC4401713 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature