Simulation predicts IGFBP2-HIF1α interaction drives glioblastoma growth.

ABSTRACT: Tremendous strides have been made in improving patients' survival from cancer with one glaring exception: brain cancer. Glioblastoma is the most common, aggressive and highly malignant type of primary brain tumor. The average overall survival remains less than 1 year. Notably, cancer patients with obesity and diabetes have worse outcomes and accelerated progression of glioblastoma. The root cause of this accelerated progression has been hypothesized to involve the insulin signaling pathway. However, while the process of invasive glioblastoma progression has been extensively studied macroscopically, it has not yet been well characterized with regards to intracellular insulin signaling. In this study we connect for the first time microscale insulin signaling activity with macroscale glioblas

SUBMITTER: Lin KW 

PROVIDER: S-EPMC4401766 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature